LAST
- Exceeding the maximum safe dose (Bupivacaine 2mg/kg),
- Lidocaine (5mg/kg)
Manifestations of Systemic Toxicity
- Minor (Associated With Low Plasma Levels)
- Perioral numbness
- Facial tingling
- Restlessness
- Tinnitus
- Metallic taste
- Vertigo
- Slurred speech
- Major (Associated With High Plasma Levels)
- Sudden loss of consciousness
- Tonic-clonic seizures
- Cardiovascular collapse
- Cardiac arrest
LAST(CNS)
LAST (CVS)
- Tachycardia & Hypertension
- Hypotension
- Wide QRS
- VF
- Cardiac arrest
MANAGEMENT
- STOP
- ACLS
- SPECIFIC 20% INTRALIPID