Fixed Drug Eruption
Characteristics and Causes
- Drug eruption that occurs at the same location every time a particular medication is used.
- Begins as an erythematous, edematous plaque with a grayish center or frank bullae, then progresses to dark, post-inflammatory pigmentation.
- Sites include the mouth, genetalia, face, and acral areas.
- Causes include phenolphthalein, tetracyclines, barbituates, sulfonamides, NSAIDs, and salicylates.
Fixed drug eruption
An acute fixed drug eruption in this patient who took Donnatal® is characterized an edematous plaque with a bullous center. Courtesy of Andrew Samel, MD.
