Leukocoria
A white pupillary reflex
Leukocoria in a Child Requires Urgent Attention
- Primarily, because in most patients with retinoblastoma, it is the first sign noticed.
- Secondarily, a white pupil indicates a severely amblyopiogenic condition, which may be treatable.
- Anatomic location is important in the differential diagnosis of Leukocoria
Causes of Leukocoria
- Cataract
- Retinoblastoma
- Toxocariasis
- Coat’s disease
- ROP
- PHPV
- Retinal detachment
- Coloboma
- Retinal dysplasia
- Norrie’s disease
Work-up
- History
- Complete ocular examination
- B Scan ultrasonography
- Intravenous fluorescein angiogram (Coats disease, ROP, retinoblastoma)
- CT or MRI
- Serum ELISA
- Anterior chamber paracentesis
- EUA
