Clinical Scenarios
Scenario (1)
A 3-year-old male with painful limp and fever. Approach?
History
- Stabilize the patient… He is stable
- Onset: 7 days
- History of Trauma: No
- Is this recurrent: No
- Fever: Febrile
- History of Hematological issues (SCD, hemophilia): No
- Recent URTI: No
- Skin rash: No
Physical Findings
- Joint or bone swelling: Yes, Right knee
- Any history of raw milk ingestion: No (consider Brucellosis)
Examination
- Vital signs: Normal
- General and systemic examinations: Normal
- Local examination:
- Right knee: swelling, tender, warm, red, limitation of movement
Diagnosis
Septic arthritis
Investigations
- CBC, Smear, ESR, CRP, blood culture
- Radiology: X-ray, ultrasound for effusion and abscess
- Aspiration for staining and culture
- Bone scan, MRI if suspected osteomyelitis
Treatment
- Admission, stabilization, analgesia
- Orthopedic consultation for joint aspiration
- Treat infection:
- < 3 months: Cefotaxime, flucloxacillin
- Or if MRSA: Clindamycin or vancomycin
- ID consultation
- Duration of treatment: 3-4 weeks
Differential Diagnosis
- Infections:
- Septic arthritis
- Osteomyelitis
- Brucellosis
- Connective tissue diseases:
- Juvenile Rheumatoid arthritis
- SLE
- Rheumatic fever
- Malignancy
- Referred pain from acute appendicitis
- Testicular torsion, orchitis
Scenario (2)
10-year-old boy with painful limping presented to the clinic. Your approach?
History
- Stabilize the patient: Stable
- Onset. Duration: 6 days
- Which limb affected and which part: Left lower limb, hip joint
- Is this 1st episode: Yes
- Any swelling: No
- Affecting his daily activity: Yes
- History of trauma: No
- Any strenuous exercise: No
- Preceding URTI, Diarrhea: No
- Any chronic illness (SCD, hemophilia): No
- Any history of chronic drug use (steroids): No
- Is he obese: Yes
Imaging
X-ray shows: Posteroinferior displacement of the left capital femoral epiphysis

Diagnosis
Slipped capital femoral epiphysis (SCFE) at left hip joint
Key questions to address:
- Risk factors?
- Clinical picture?
- Differential diagnoses?
- Complications?
- Treatment?
- Prognosis?
Scenario (3)
10-year-old female brought with 2 months history of fever, bone pain, fatigability, limping. Your approach?
History
- Stabilize the patient: Stable
- Nocturnal symptoms of fever, sweating: No
- Weight loss: Mild, due to poor appetite
- History of skin rash: No
- History of morning stiffness: No
- History of taking raw milk or contact with animals: Yes, 3 months back she was in contact with goats
- Family history of similar problem: No
Examination
- Vital signs and anthropometric measurements: Normal but febrile
- Pallor: Some pallor
- Jaundice: Not clear
- Hepatosplenomegaly or lymphadenopathy:
- Liver: moderate enlargement
- Spleen: 7 cm
- No lymphadenopathy
- She received many antibiotics without response
Investigations
CBC:
- Microcytic hypochromic anemia
- Leukocytes: normal differential, mild neutrophils
- Thrombocytosis
Diagnosis
Brucellosis
Not leukemia, lymphoma or any malignancy
Diagnostic Tests
- Titer of Brucella
- PCR
- Brucella culture (1-2 weeks, but can take 6 weeks)
Treatment (>8 years)
Doxycycline + Rifampicin for 6 weeks – Bactrim
Scenario (4)
Ahmed is 10 years old, brought to the ER by his mother because he is limping. Approach.
History
- Duration: 3 days
- Which limb is affected: Right lower limb
- Which part of the right lower limb: Mainly the groin area
- Any other area or joints pain: Yes, Right thigh and knee
- Can he bear weight on the right lower limb: No
- Skin rash: No
- Febrile, ill or toxic: No
- Loss of weight or night sweating: No
- History of trauma or contusion: No
- Is he obese: No
- Past history of hematological problem (SCD) or blood transfusion: No
- Past history of similar problem: No
- History of URTI within the last weeks: Yes, mild cough, runny nose and mild fever 7 days ago
- Family history of similar problem: No
- History of chronic medication: No
Examination
Full examination (general examination, vital signs, measurements, skin, HSM, lymph nodes, etc.): No abnormality detected
Local Examination
- Pain in the right hip radiating to thigh and knee
- Cannot bear weight on the right lower limb
Investigations
- FBC, peripheral blood film, ESR and CRP: Normal
- X-ray lateral and AP: Widening of joint space
- Ultrasound: Mild to moderate joint effusion
Diagnosis
Transient synovitis of the right hip joint
Serious Differential
- Septic arthritis
How to Differentiate
- Synovial fluid study