- It is prepheral symmetrical polyneuropathy .
- Motor nerve affection can lead to Ptosis,foot drop.
- Sensory nerves affection more common than motor nerves .
sensory nerve affection of feet and hand called ’’Glove and Stocking’’ with the following manifestations:
- numbness and paresthesia(altered sensation),burning,tingling
- loss of pain sensation ⇒ unnoticed injury.
Complications :
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ulceration (painless) with diffcult healing due to diffuse vascular injury.
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charcot neuroarthropathy: damage of weight bearing joints as knee and ankle joints also damage of tarsal and metatarsal joints in foot.
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Callosities: hardening and thickning of skin specially in pressure areas with prolonged friction.
Diabetic foot Pathogenesis
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decrease sensitivity ⇒ unnoticed injury ⇒ infection.
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autonomic dysfunction of sweat glands ⇒ skin fissure, cracks, callus.
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motor nerve dysfunction ⇒ high arched foot and susceptibility to injury.