Y Multiple Triggering Mechanisms
- Drugs (general anesthesia, succinylcholine)
Triggering Mechanism Affects reuptake of calcium by sarcoplasmic reticulum necessary for termination of muscle contraction. It results in:
- Massive Muscle Contraction
- Excessive Lactate Production (acidosis, tachycardia, hypercarbia, hypoxemia).
- Pronounced Increase In body Temperature due to unccoupling oxidative phosphorylation.
Teatment:
- I.V dantrolene.
- Interferes with excitation-contraction coupling
- Reduces release of Ca++ from the sarcoplasmic reticulum
- Blocks contraction
-
cooling.
-
corecxt acidosis.