Chemically related to sulfonamides
- Systemic: Acetazolamide (Diamox), Methazolamide
- Topical: Dorzolamide (Trusopt), Brinzolamide (Azopt)
- Uses: glaucoma, cystoid macular edema, pseudo-tumour cerebri
- Mechanism: aqueous suppression
- Side effects: paresthesia (extremities and mucocutaneous junction), anorexia, GI upset, headache, altered taste and smell
- K depletion (hypokalemia), metabolic acidosis, renal stone, bone marrow suppression “aplastic anemia”, Steven-Johnson syndrome
- Contraindications: sulpha allergy, sickler pts, and pregnancy