Scurvy (Vitamin C Deficiency)
Pathophysiology
- Failure of collagen & osteoid formation → Weak osteoid matrix
Clinical Features
- In children:
- Irritability
- Anemia
- Bleeding gums
- Painful swellings at ends of long bones
Radiological Features
- Osteopenia at metaphysis
- Sub-periosteal bleeding & peri-osseous calcification
- Ring sign in epiphysis
Treatment
- Vitamin C supplementation (large doses)