Metabolic Bone Disorders

Prof. Mamoun Kremli

TOC

• Physiology of Bone

• Bone Scans

Objectives

• Bone as an active tissue
• Calcium as an important mineral
• Calcium metabolism – normal control
• Metabolic bone diseases:
  • Osteoporosis
  • Rickets and Osteomalacia (very rare)
  • Hyperparathyroidism
  • Scurvy

Common Metabolic Bone Diseases

• Osteoporosis
• Rickets
• Osteomalacia
• Hyperparathyroidism (osteitis fibrosa)
• Scurvy

Summary

Key Concepts

• Bone is an active tissue:
  • Continuous absorption and rebuilding
• Calcium is an important mineral (more critical than phosphate)
• Calcium control involves multiple factors:
  • Vitamin D, PTH, Calcitonin, Steroids, estrogen, mechanical stress, etc.

Metabolic Bone Diseases Covered

• Osteoporosis: Reduced bone mass
• Rickets and Osteomalacia: Defective mineralization
• Hyperparathyroidism: Excess PTH effects
• Scurvy: Vitamin C deficiency affecting collagen