Solitary areas of lysis, sclerosis or a combination of the two, are usually one of the following:
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Bone tumour – Malignant (primary or secondary) – Benign
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Osteomyelitis
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Non-neoplastic defect of bone such as bone cyst and fibrous dysplasia.
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Conditions of uncertain nature such as Langerhans’ histiocytosis and osteoid osteoma.