Z They inhibit beta-1,3-D-glucan synthase, the enzyme responsible for the production of beta-1,3-D -glucan, a glucose polymer that is necessary for maintaining the structure of fungal cell walls. In the absence of this polymer, fungal cells lose integrity and lysis quickly follows (cidal).
Examples:
***caspofungin, micafungin, anidulafungin: ***
- They are excellent fungicidal activity against Candida and useful activity against Aspergillus.
- They have considerably fewer drug interactions than azoles, are safer than polyenes, and have great activity against fluconazole-resistant yeasts.
Uses:
Echinocandins are drugs of choice for ***invasive candidiasis ***
Side effects:
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infusion reaction; Echinocandins can cause mild histamine-mediated infusion-related reactions, (flushing) when infused too rapidly. and can be ameliorated by slowing the infusion rate.
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Also, fever, rash, nausea, phlebitis at the infusion site
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Hepatotoxicity is also possible with any of the