Types of Alpha Thalassemia
| Type | Genotype | Description |
|---|---|---|
| α-thalassemia minor | αα/— | Slightly anemic, low MCV and MCH; clinically asymptomatic |
| HbH disease | α,-/-,- | HbH. Anemic, very low MCV and MCH; splenomegaly, variable bone changes |
| α-thalassemia major | -,-/-,- | Hb Bart’s. Severe non-immune intrauterine hemolytic anemia. Hb Bart’s hydrops fetalis, usually fatal. |
Alpha-Thalassemia Genetics and Clinical Consequences
