Calcipenic Rickets
Causes:
- Calcium deficiency
- Vitamin D deficiency (Nutritional or Lack of sunlight)
- 25 hydroxylase deficiency– conversion of cholecalciferol to calcidiol (liver disease)
- 1-alpha hydroxylase deficiency causing failure of 1-hydroxylation of vitamin D (renal disease) (Vitamin D Dependent Rickets type I – VDDR I)
- End Organ Vitamin D receptor resistance (VDDR II)
- Anticonvulsant medications e.g., phenytoin
Treatment A) Hypocalcemia - IV 10% calcium gluconate 2-3ml/kg followed by IV calcium infusion - Shift to oral supplements for maintenance - Vitamin D supplements