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Myelofibrosis: Proliferation of mesenchymal elements (connective tissues) bone marrow fibrosis, spleen, liver, lymph nodes & extramedullary haemopoieses.
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Seen in over 50 age group.
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Huge splenomegaly & infarct causes discomfort.
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Splenectomy relieves symptoms.
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Tumours: Large haemangioma, Non-Hodgkin’s lymphoma confined to spleen-splenectomy