Tamoxifen (partial estrogen agonist):
- 20 mg / day for 5 years for pre and postmenopausal
Aromatase inhibitors (blocks conversion of androgens to estrogen):
- letrozole, anastrozole, exemestane
- Used in Postmenopausal women, hormone receptor +ve tumors
Oophorectomy:
- Women <50, ER +ve tumors, metastatic disease (surgical or radiation)
Anti-HER 2 Therapy
- 15-20% tumor express HER2
- Worse prognosis than HER2 negative tumors.
- Humanized monoclonal antibody:-
- Trastuzumab (Herceptin)