Lamotrigine
- Especially helpful from down-up
- More effective in preventing depression
- Less weight gain
- Watch for any rash
- (5-10%) Stevens-Johnson syndrome a possibility, (1/5000), thus D/C.
- Start at 12.5-25 mg PO OD
- Increase by 12.5-25 mg PO q1-2weekly
- Levels – Usually 50-200 mg/day
- No blood level monitoring necessary
Indications
- Mania
- Level III evidence (D)
- Depression
- Level I evidence (A)
- Prophylaxis
- Level I evidence (A)