Olanzapine
- Has been HPB approved as anti-manic, but also as monotherapy in bipolar
- I would not go this route due to effects of increased weight, increased glucose, triglycerides, and lipids
- Olanzapine and clozapine have more weight gain than risperidone and quetiapine
- Possible link to diabetes type 2
Indications
- Mania
- Level I evidence (A)
- Depression
- Level I evidence (B)
- Prophylaxis
- Level I evidence (A)