Clozapine (Clozaril)
Clozapine (Clozaril)
- Is reserved for treatment resistant patients because of side effect profile but this stuff works!
- Associated with agranulocytosis (0.5-2%) and therefore requires weekly blood draws x 6 months, then Q 2weeks x 6 months)
- Increased risk of seizures (especially if lithium is also on board)
- Associated with the most sedation, weight gain and transaminitis
- Increased risk of hypertriglyceridemia, hypercholesterolemia, hyperglycemia, including nonketotic hyperosmolar coma and death with and/or without weight gain