Loop diuretic
- Furosemide
- Piratanide >>>
- isachrinic acid??
- Inadranon??
Very pontent and rapid onset drugs - gives good diuresis, results in vasodilation, hypokalemia - used in hypertensive emergencies, acute heart failure
Thiazide
- Hydrochlorothiazide
- Bendroflunethiazide
- Imdadapime (diuertic and calcium channel blocking efects)
Delayed onset - Diuresis, hypokalemia, after 3-4 weeks it results in vasodilation - Used in mild to moderate hypertension & chronic heart failure
Potassium sparing diuretics (cc) ex…
- Spirinolactone (Gynecomastia)??
- Iblimorone??
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Used in 2ry hypertention - such as hyper-aldesterone if hypokalamia due hypertensive drugs happened due to thiazide or loop diueretic
IN HF
Measures to control excessive retention of salt and water = Diuretics
They are usually the first line of treatment.
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Increase in urinary sodium excretion leading to reduction in blood and plasma volume.
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May also cause a small but significant degree of arterial and venous dilatation.
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Therefore diuretics reduce preload and improve pulmonary and systemic venous congestion, reduce afterload and ventricular volume with fall in wall tension and increase cardiac efficiency.
We start with loop diuretic as furosemide and we can add thiazide and spironolactone.
N.B: Potassium sparing agents has the following roles:
- Additive diuresis
- Improve heart viability
- Improve the left ventricular ejection fraction
- Decrease the cardiac arrhythmia.