Mechanism of Action
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In the presence of acid it acts to protect the gastric and duodenal mucosa from acid pepsin attack through formation of complex with proteins at the ulcer site (ulcer crater) to form a protective layer against acid, pepsin, bile.
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It decreases back diffusion of H+ and binds to pepsin, bile salts
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It increases secretion of endogenous prostaglandins.
Pharmacokinetics
Slightly absorbed from G.I.T, excreted in stools and urine.
Uses
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In duodenal and gastric ulcer to promote healing and decrease recurrence.
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Safe in pregnancy
Adverse Effects
It has few side effects as it is not absorbed systemically and acts locally:
- Constipation
- decreased bioavailability of tetracycline, digoxin and phenytoin can occur. This is due to decreased rate of absorption of these drugs if they are administered concurrently with sucralfate.