It is a life-threatening medical emergency due to stress truama that is more common in old age - usually living alone - Mainly DM 2 Manifestation. Hyperglycemia causes to ↑ water loss (osmotic diuresis) with little sodium loss → severe dehydration and hyperosmolarity.

Treatment: similar to DKA except in:

  1. Fluids: rapid and aggressive i.v. isotonic saline: the principal treatment.
  2. Insulin is needed in smaller amount than in DKA. Insulin used without concomitant vigorous fluid replacement increases the risk of shock.
  3. Hypokalemia is usually less marked .
  4. Low dose of heparin to prevent thrombotic complications.