Synthetic PGE1 analogue (Misoprostol)
Mechanism of Action
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Inhibition of gastric acid secretion by the parietal cells due to inhibition of histamine stimulated cAMP production.
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Cytoprotective effect on gastric and duodenal mucosa with increased mucus and bicarbonate secretion
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Maintains gastric mucosal blood flow and stimulates mucosal cellular regeneration.
Uses
- Treatment of peptic ulcer
- Prevention and treatment of mucosal damage induced by NSAID.RR
Adverse Effects
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Diarrhea due to promoting secretion of fluid and electrolyte into the lumen of bowel and decreasing intestinal segmentary contractions that retard flow of luminal contents. RR
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Uterine contractions and abortion So, It is contraindicated during pregnancy