Tigecycline, a derivative of minocycline, is the first available member of the glycylcycline antimicrobial class.
Uses: It is indicated for parenteral treatment of complicated skin and soft tissue infections, complicated intra-abdominal infections in adults.
Mechanism of action: Tigecycline exhibits Static action by reversibly binding to the 30S ribosomal subunit and inhibiting protein synthesis.
ANTIBACTERIAL SPECTRUM
Tigecycline exhibits broad-spectrum activity that includes:Â
methicillin resistant staphylococci (MRSA), multidrug-resistant streptococci, vancomycin-resistant enterococci (VRE), extended-spectrum β-lactamase (ESBL) –producing gram negative bacteria, and many anaerobic organisms.   Â
- However, it is not active against Proteus, or Pseudomonas species
ADVERSE EFFECTS: As tetrayclines and :
- ♣ Significant severe nausea ,vomiting and diarrhea although it is IV drug.
- ♣ Acute pancreatitis, including fatality, has been reported with therapy.
- ♣ Elevations in liver enzymes and serum creatinine
- ♣ Tigecycline may decrease the clearance of warfarin and increase prothrombin time