synthetic, broad-spectrum, bactericidal antibiotic with activity against large number of Gram-negative and Gram- positive organisms including E. coli, Klebsiella spp., Proteus spp., Pseudomonas spp., and VRE.
Fosfomycin is available in an oral formulation only in the U.S. and its pharmacokinetics allow for one-time dosing.
((Acts on gram negative and positive)) – used only when all other drugs failed to treat – so used broad spectrum.