was first aminoglycoside to become available for clinical use: 1- (Treatment of tuberculosis) and TB meningitis (intrathecal) (never alone) .
2- With penicillin-G or ampicillin, in the treatment of Streptococcal viridans and Enterococcal endocarditis infections and *as prophylaxis in persons with known valvular disease undergoing surgery. *
3- used in septicemia, usually combined with BENZYL PENICILLIN, or (Metronidazole) *if anaerobes are thought to be present (e.g. peritonitis) *
4- treatment of plague, tularemia and brucellosis.
- Family prototype
- TB (Never Alone), Meningitis (Intrathecal)
- Synergetic affect with Pen-G/Ampicillin (Strept. Viridans and Enterococcal endocarditis)
- Prophylaxis in Valvular disease or surgery
- Septicemia with Pen-G or Metronidazole if anaerobes is suspected
- Others: Tularemia, Plaque, Brucellosis