Mechanism of Action
It increases production, secretion and viscosity of mucus, so increases mucosal resistance. In addition, it affects the metabolism of PG E, F and decreases pepsin activity.
Uses
- Treatment of gastric ulcer
- Treatment of oesophagitis
- Treatment of duodenal ulcer.
Adverse Effects
Na+-retention and hypokalemia (aldosterone-like effect): ⇒ This leads to edema, hypertension and heart failure especially in elderly and in cardiac, renal and hepatic patients.