Approach to Patients with Chest Pain

General Rule

  • As a general rule, any chest pain is ischemic in origin until proven otherwise!

Aetiology

A retrospective study in the US, conducted over a 5-year period, of patients aged over 35 years, with a chief complaint of non-traumatic chest pain admitted to hospital from the emergency department, found that chest pain most frequently had a coronary cause.[7] Pulmonary embolism and aortic dissection were rare but important causes.[7]

  • 29.4% atypical chest pain
    (ruled out acute myocardial infarction and angina/coronary heart disease; no serious cause established)
  • 22.5% angina/coronary artery disease
  • 10.7% acute myocardial infarction
  • 13.8% other cardiac causes
    (mostly congestive cardiac failure, atrial fibrillation, and other dysrhythmias)
  • 11.2% non-PE pulmonary causes
    (includes pneumonia and pneumothorax)
  • 10.2% other
  • 1.6% abdominal causes
    (includes cholecystitis, pancreatitis, ulcer)
  • 0.4% pulmonary embolus
  • 0.3% aortic dissection

Etiologies

  • Myocardial ischemia or infarction
  • Pulmonary embolus
  • Pneumothorax
  • Pericarditis
  • Tamponade
  • Pneumonia
  • Aortic dissection
  • Gastritis, peptic ulcer disease
  • Musculoskeletal
  • Shingles

Chest Pain Classification

Retrosternal Pain

  • Myocardial ischemic pain
  • Pericardial pain
  • Esophageal pain
  • Aortic dissection
  • Mediastinal lesions
  • Pulmonary embolization

Interscapular Pain

  • Myocardial ischemic pain
  • Musculoskeletal pain
  • Gallbladder pain
  • Pancreatic pain

Right Lower Anterior Chest Pain

  • Gallbladder pain
  • Distention of the liver
  • Subdiaphragmatic abscess
  • Pneumonia/pleurisy
  • Gastric or duodenal penetrating ulcer
  • Pulmonary embolization
  • Acute myositis
  • Injuries

Epigastric Pain

  • Myocardial ischemic pain
  • Esophageal pain
  • Duodenal pain
  • Pancreatic pain
  • Gallbladder pain
  • Distention of the liver
  • Diaphragmatic pleurisy
  • Pneumonia/pleurisy

Left Lower Anterior Chest Pain

  • Intercostal neuralgia
  • Pulmonary embolization
  • Myositis
  • Pneumonia/pleurisy
  • Splenic infarction
  • Splenic flexure syndrome
  • Subdiaphragmatic abscess
  • Precordial catch syndrome
  • Injuries

Shoulder Pain

  • Myocardial ischemic pain
  • Pericarditis
  • Subdiaphragmatic abscess
  • Diaphragmatic pleurisy
  • Cervical spine disease
  • Acute musculoskeletal pain
  • Thoracic outlet syndrome

Arm Pain

  • Myocardial ischemic pain
  • Cervical/dorsal spine pain
  • Thoracic outlet syndrome

Typical vs. Atypical Chest PainZ

Typical Chest Pain

  • Discomfort/pressure rather than pain
  • Time duration >15 mins
  • Provoked by activity/exercise
  • Radiation (i.e. arms, jaw)
  • Does not change with respiration/position
  • Associated with diaphoresis/nausea
  • Relieved by rest/nitroglycerin

Atypical Chest Pain

  • Pain that can be localized with one finger
  • Constant pain lasting for days
  • Fleeting pains lasting for a few seconds
  • Pain reproduced by movement/palpation

Symptoms Suggestive of ACS

  • Pain in upper arms, back or jaw, that lasts longer than 15 minutes

  • Pain in combination with nausea, vomiting, sweating & breathlessness.

  • Pain in combination with dizziness or feeling light-headed

  • New onset chest pain, or a sudden deterioration in previously stable angina.

  • Additional factors that increase the likelihood of a cardiac cause of chest pain are:

    • Older age
    • Male sex
    • A high number of predisposing clinical features, e.g. smoking, diabetes & obesity.

Non-Cardiac Chest Pain

Pulmonary Causes

  • Pneumonia
  • Pleuritis
  • Pneumothorax
  • Pulmonary Embolism
  • Tumor

Gastrointestinal Causes

  • GERD
  • Esophageal spasm
  • Mallory-Weiss Tear
  • Peptic Ulcer disease
  • Biliary/Gallbladder Disease
  • Pancreatitis

Musculoskeletal Causes

  • Costochondritis
  • Cervical Disk Disease
  • Rib Fracture
  • Intercostal Muscle Cramp

Other Causes

  • Herpes Zoster
  • Disorders of the Breast
  • Splenic Infarct
  • Panic attacks & Anxiety Disorder
  • Fibromyalgia
  • DKA

Cardiac Chest Pain

  • Aortic Dissection
  • Pulmonary Embolism
  • Pulmonary Hypertension
  • Pericardial Diseases
  • Aortic Stenosis
  • Heart Failure
  • Cocaine Abuse

Acute Coronary Syndromes

Stable Angina Unstable Angina Myocardial Infarction Cardiogenic Shock