(Pirenzepine and telenzepine)
Mechanism of Action
Selective blocker of peripheral M1 muscarinic receptors of gastric parietal cells, so it suppresses basal gastric acid secretion with less effect on secretion stimulated by food in the stomach.
Uses
- Useful in patients refractory to treatment with H2-receptor antagonists alone or those with nocturnal pain.
- (Because of their relatively poor efficacy and undesirable side effects they rarely are used).
Side Effects
Untoward effects of cholinergic blockade (dry mouth, mydriasis, glaucoma, constipation, tachycardia and urine retention).