Itraconazole is wider spectrum of activity than ketoconazole and fewer adverse effects. Drug of choice for several systemic infections.
Is an in-between agent, with a broader spectrum than fluconazole but narrower than voriconazole, posaconazole, and isavuconazole
Side effects:
- Hepatotoxicity
- QTc prolongation,
- itraconazole is a negative inotrope and is ontraindicated in patients with heart failure.
- The oral solution is associated with diarrhea.
- It is also a potent inhibitor of cytochrome P450 enzymes and has a long list of drug interactions.