Tricyclics (TCAs)
TCAs
- Very effective but potentially unacceptable side effect profile i.e. Side chains are prone to cross react with other types of receptors which leads to more side effects including antihistaminic (sedation and weight gain), anticholinergic (dry mouth, dry eyes, constipation, memory deficits and potentially delirium), antiadrenergic (orthostatic hypotension, sedation, sexual dysfunction)
- Lethal in overdose .
- Can cause QT lengthening even at a therapeutic serum level
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