Mechanism of Action
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In the presence of acid, they act locally by selective binding with exudates, mucus and protein in the base of the ulcer crater, coating and protecting it from acid and pepsin. (as ?)
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It inhibits pepsin activity and increase mucus and PG synthesis.
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It has some antimicrobial activity against gastric Helicobacter pylori.
Uses
Promoting healing of duodenal ulcer and gastric ulcer.
Adverse Effects
Minimal effects e.g. stool and teeth discoloration (black). Chronic use causes encephalophathy especially in renal failure due to accumulation of bismuth.