Candidiasis

C. albicans - Normal intestinal flora in 40-80% of healthy people. • They also isolated from oral cavity, vagina& rectal area

Clinical diseases:Z

• Superficial lesion
• Mucous membrane:
  1. Oral thrush: discrete white patches on mucosal surface.
  2. -Vaginal thrush: white lesion on vulva, vagina and cervix.
• Skin: Infection occurs in moist warm area as axilla, groin, submammary fold
• Nail: Infection of finger web, nail fold
• Chronic mucocutaneous (CMC) candidiasis

Systemic lesion:

• Candidal endocarditis: follows heart valve surgery.
• Candidaemia

Clinical diseases caused by aspergillosis

• Superficial Aspergillosis: Fungal colonization in:

  1. paranasal sinuses,
  2. external ear,
  3. eye

• Respiratory disease:

  1. Bronchial asthma: following inhalation of spores.
  2. Broncho-pulmonary Aspergillosis: the hyphae occlude lumen of bronchioles.
  3. Aspergilloma: Called fungus ball occur on preexisting lung cavity e.g. TB.

• Invasive Aspergillosis: Haematogenous spread from lung to other organs.