Propofol (2, 6- diisopropylphenol)
- Mechanism of Action: Facilitates inhibitory neurotransmission by enhancing the function (GABAA) receptors in CNS.
- Pharmacokinetics: Hepatic and extrahepatic metabolism leads to inactive metabolites which are excreted by renal route.
- Pharmacodynamics:
- CNS: Induction: rapid onset of unconsciousness (30 to 45 seconds), followed by a rapid termination of effect by redistribution.
- Cardiovascular System: Dose-dependent ↓ in preload, afterload, and contractility lead to ↓ in (BP) and COP.
- Respiratory System: Dose-dependent decrease in (RR) and (TV). ↓Ventilatory response to hypoxia and hypercarbia.
- Advantages:
- Antiemetic properties.
- Suitable for day case surgery.
- Situations where volatile anesthetics cannot be used (MH).
- No histamine release.