Mechanism of action:
Ferrodoxine Oxidoreductase enzyme
Indications:
- Tissue amoebicidal: (intestinal,hepatic,pulmonary)
- Giardiasis
- Trichominasis
- Anaerobic infection: e.g
- serious infection caused by bacteroid fragilis
- enterocolitis cause by cl.difficil
- acute ulcerative vaginitis
- decubitus lesion; bed sores
- to reduce postoperative infection following abdominal surgery
- H. Pylori - *mention other three indicated for the microbe Clarithromycins, Ampicillin & Amoxicillin, Tetracyclines
Side effects:
- GIT: bad taste in mouth,angular stomatitis,dry mouth
- Dark red urine
- CNS: headache, insomnia, parathesia
- Blood:leucopenia & thrombocytopenia
- Disulfiram like reaction in alcoholism; like Cefoprazone; cephalosporins
- Phlebitis if given IV
- Mutagenesis and carcinogenesis in mammalian cell culture
Contraindication & CautionsY
not usually taken in consideration, due drug is not used for prolonged time
- Be caution if prescribe drugs to:
- Patients with hepatic, brain, or blood disorders.
- Don’t give it to pregnant , lactating or young age.
- It increases the effects of oral anticoagulant by decreasing its metabolism.