cutaneous mycotic infections

Drugs for cutaneous mycotic infectionsZ

1. Squalene epoxidase inhibitors (Terbinafine, naftifine, butenafine) blocking the biosynthesis of ergosterol
2. Griseofulvin (Was the first drug ⇒ Long Coursing) disrupt the mitotic spindle and inhibit mitosis
3. Nystatin cutaneous and oral Candida infections
4. Imidazoles; Clotrimazole, Miconazole, Ketoconazole
5. CiclopiroxY
6. TolnaftateY
7. TERPENOIDS (Ibrexafungerp)Y

Mold-like fungi that cause cutaneous infections are called dermatophytes or tinea. Three different dermatophyte fungi that cause the majority of cutaneous infections are: Trichophyton, Microsporum, Epidermophyton.

Tinea infections are classified by the affected site:Y

Tinea pedis, athletes foot - ringworm of foot, an infection of the feet.

• Squalene epoxidase inhibitors;Terbinafine Topical
• Imidazoles Topical; Clotrimazole, Miconazole, Ketoconazole

Tinea corporis (ringworm), an infection of the body

• Squalene epoxidase inhibitors;Terbinafine Topical
• Imidazoles Topical; Clotrimazole, Miconazole, Ketoconazole

Tinea capitis =ringworm of scalp

• Squalene epoxidase inhibitors;Terbinafine Oral - faster duration
• Griseofulvin; Oral - but long duration of treatment

Tinea cruris (groin) “jock itch”

• Squalene epoxidase inhibitors;Terbinafine Topical

• Imidazoles Topical; Clotrimazole, Miconazole, Ketoconazole

Tinea barbae (beard)

Tinea faciei (face)

Tinea manuun (hand)

Tinea unguium (nail) Griseofulvin; Oral

Note: Common dermatomycoses, such as tinea infections that appear as rings or round red patches with clear centers, are often referred to as “ringworm.”