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Serotonin Receptor Agonists (Triptans):
Serotonin Receptor Agonists (Triptans): Drugs Sumatriptan, rizatriptan Pharmacokinetics All triptans (except sumatriptan) have high oral bioavailability & long half-lives
Therapeutic Uses Used for patients with moderate to severe migraine or when other medications are ineffective. Mechanism of Action selective agonists of 5HT1B and 5HT1D receptors which cause vasoconstriction.
Side Effects Paresthesias, fatigue, dizziness, Chest tightness, pain in chest, neck, or throat Contraindication Ischemic heart disease, Uncontrolled hypertension, Cerebrovascular disease.