e.g. Aztreonam Spectrum: monocyclic B-lactams Excellent Gram –ve; poor against Gram +ve & Anerobes Pros: Resistant to most Beta Lactamases, Less likely to cause hypersensitivity
Aztreonam is stable to most B-lactamases. It has a low potential to produce hypersensitivity reactions, even in patients with known B-lactam allergy. the drug can be administered via inhalation to patients with Cystic Fibrosis to prevent exacerbations of infection. and also used in severe infection
Used in Gram-negative infections, including Pseudomonas, particularly in patients with a history of beta lactam allergy. must be admitted to hospital for administration.