Tumor >2 cm but not more than 4 cm in greatest dimension
T3
Tumor >4 cm in greatest dimension or extension to lingual surface of the epiglottis
T4a
Moderately advanced, local disease
T4b
Very advanced, local disease
Regional Lymph Nodes (N)
N0
No regional lymph node metastasis
N1
Metastasis in a single ipsilateral lymph node ≤3 cm in greatest dimension
N2
Metastasis in a single ipsilateral lymph node >3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none >6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none >6 cm in greatest dimension
N3
Metastasis in a lymph node >6 cm in greatest dimension
Distant Metastasis (M)
M0
No distant metastasis
M1
Distant metastasis
Histologic Grade (G)
GX
Grade cannot be assessed
G1
Well differentiated
G2
Moderately differentiated
G3
Poorly differentiated
G4
Undifferentiated
Classification and Staging
Primary Tumor
T1: Tumor limited to one site with normal vocal cord mobility.
T2: Tumor extending to more than one site with normal vocal cord mobility.
T3: Tumor limited to larynx with vocal cord fixation.
T4: Tumor extending beyond the larynx.
Lymph Nodes (N)
N0: No clinically positive nodes.
N1: Single clinically positive ipsilateral node 3 cm or less in diameter.
N2: Single clinically positive node more than 3 cm but less than 6 cm in diameter.
N3: Massive ipsilateral nodes (>6 cm), bilateral or contralateral nodes.