These agents act by inhibiting squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an essential component of the fungal cell membrane which results in increased membrane permeability and death of the fungal cell.
- 1 month
Terbinafine
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Oral terbinafine is the drug of choice for treating fungal infections of nails also known as dermatophyte onychomycoses and tinea capitis .
Note: Topical application is not effective. -
Topical terbinafine (1% cream, gel or solution) is used to treat: tinea pedis , tinea corporis , and tinea cruris . - Any type except _______________
Terbinafine accumulates in breast milk and should not be given to nursing mothers.
Naftifine and Butenafine
Naftifine is Broad spectrum, fungicidal active against Trichophyton, Microsporum, and Epidermophyton.
Naftifine 1% cream and gel are used for topical treatment of tinea corporis, tinea cruris, and tinea pedis. Duration of treatment is usually 2 weeks.
Butenafine like naftifine, is used for topical treatment of tinea infections.