it is a dye of complex structure - No cross resistance .
Mechanism of action
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bind to mycobacterial DNA and inhibit mycobacterial replication and growth.
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Clofazimine is given orally and tend to accumulates in the body, being sequestered in the mononuclear phagocyte system. The plasma half-life may be as long as 8 weeks. The antileprotic effect is delayed and is usually not evident for 6-7 weeks.
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It also has anti-inflammatory activity and is useful in patients in whom dapsone causes inflammatory side effects. • the anti-leprotic effect is delayed (after 6-7 weeks) • the plasma half –life may be as long as 8 weeks
Unwanted effects of clofazimine
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Unwanted effects may be related to the fact that clofazimine is a dye. The skin and urine can develop a reddish colour and the lesions a blue-black discoloration.Z
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Dose-related nausea, giddiness, headache and gastrointestinal disturbances can also occur